Adults One to two drops instilled into the conjunctival sac two to four times daily. During the initial 24 to 48 hours the dosing frequency may be safely increased to 2 drops every hour. Care should be taken not to discontinue therapy prematurely. No overall differences in safety or effectiveness have been observed between elderly and younger patients. To reduce possible systemic absorption, it may be recommended that the lacrimal sac be compressed at the medial canthus (punctal occlusion) for 1 minute. Acute superficial herpes simplex (dendritic keratitis); vaccinia, varicella and most other viral diseases of the cornea and conjunctiva. Mycobacterial infection such as tuberculosis of the eye. Paediatric population The safety and efficacy in paediatric population have not yet been established. This should be performed immediately following the instillation of each drop. Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. Acute purulent infections of the eye may be masked or enhanced by the use of topical steroids. If infection is present, appropriate measures must be taken to counteract the infective organisms. Prolonged use may also suppress the host immune response and thus increase the hazard of secondary ocular infections. Prednisolone acetate ophthalmic suspension (eye drops) is an adrenocortical steroid product, prepared as a sterile ophthalmic suspension and used to reduce swelling, redness, itching, and allergic reactions affecting the eye. Although there are no major human studies of prednisolone use in pregnant women, studies in several animals show that it may cause birth defects including increase cleft palate. Prednisolone should be used in pregnant women when benefits outweigh the risks and children born from mothers using prednisolone during pregnancy should be monitored for impaired adrenal function. Prednisolone is found in breast milk of mothers taking prednisolone. As a glucocorticoid, the lipophilic structure of prednisolone allows for easy passage through the cell membrane where it then binds to its respective glucocorticoid receptor (GCR) located in the cytoplasm. Upon binding, formation of the GC/GCR complex causes dissociation of chaperone proteins from the glucocorticoid receptor enabling the GC/GCR complex to translocate inside the nucleus. Once inside the nucleus, the homodimer GC/GCR complex binds to specific DNA binding-sites known as glucocorticoid response elements (GREs) resulting in gene expression or inhibition. Complex binding to positive GREs leads to synthesis of anti-inflammatory proteins while binding to negative GREs block the transcription of inflammatory genes.
Steroid eye drops - Maxidex vs Pred Forte? - Sarcoidosis. malina571. July 12, 2011 at am;. which I had before. However before I was treated with Pred Forte eye drops prednisolone, highly effective, no side effects. Also prescribed by retina specialist - different one obviously. However, I googled this topic maxidex vs. Pred Forte contains no antimicrobial agent. If infection is present, appropriate measures must be taken to counteract the infective organisms. Prednisolone acetate has, on a weight to weight basis, a potency three to five times that of hydrocortisone. 5.2 Pharmacokinetic properties.