Orlistat is a powerful medication meant for people who are overweight or obese. Both Alli and Xenical are specifically approved to be taken only while also adhering to a low-calorie diet and exercise program. The OTC version, Alli, contains half as much as orlistat as doctor-prescribed Xenical does. Orlistat works by blocking enzymes in the gut that normally digest fat, thus preventing its absorption. (During our review of the latest information one of our medical consultants commented that "fat malabsorption," as the condition is known, is actually a disease.) But that lack of absorption can lead to a number of adverse effects. In clinical trials of Xenical, during the first year of use, 27 percent of people experienced oily underwear staining, 24 percent had gas with involuntary discharge of stool, 22 percent experienced fecal urgency, 11 percent had an increased number of bowel movements, and 8 percent suffered fecal incontinence. Virtually everyone who takes orlistat experiences diarrhea, at least, occasionally. The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug. ORLISTAT - ORAL (OR-lih-stat) COMMON BRAND NAME(S): Xenical This medication is used with a reduced-calorie diet to help significantly overweight persons lose weight. It also helps to prevent regaining weight previously lost. Orlistat works by blocking some of the fat normally digested by the intestine. Take this drug by mouth, generally three times daily during (or up to one hour after) each main meal that contains fat.
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