(Note: Due to differences in absorption the three forms have different dosages). In its free base form it is unstable at gastric p H so it is administered as a salt form (stearate or estolate) or with an enteric coating. Its most common side effect is gastrointestinal upset. Clarithromycin and azithromycin are structural derivates of erythromycin with a broader spectrum of activity and increased bioavailability. Both agents exhibit less gastrointestinal upset than erythromycin. Macrolides are bacteriostatic rather than bacteriocidal and thus are not recommended in immuno-compromised patients. In the past, macrolides were considered highly effective antibiotics for treating dental infections and frequently substituted in penicillin allergy. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Preterm premature rupture of membranes (PPROM) complicates 4% of pregnancies annually. Listing a study does not mean it has been evaluated by the U. This pregnancy complication is a major contributor to preterm births and results in neonatal morbidity and mortality. The current standard of care for PPROM subjects between the gestational age of 24 weeks and 0 days and 33 weeks and 6 days, is to administer ampicillin and erythromycin for a total of 7 days. Erythromycin can cause GI upset and some subjects do not tolerate this regimen over the course of 7 days. In addition, there is a national shortage of erythromycin, and published expert opinion proposed to use a second-generation macrolide (azithromycin) instead of erythromycin. Azithromycin can be taken once daily, is cheaper than erythromycin and has less GI upset adverse effects. The investigators' objective is to compare the effectiveness of the 2 regimens in prolonging pregnancy after PPROM.
Azithromycin is an antibiotic used to treat a variety of different infections. It has the distinct advantage of once-daily dosing; however, diarrhea is a common side effect. Prescribed for Chlamydia Infection, Sinusitis, Upper Respiratory Tract Infection, Bacterial Infection, Babesiosis, Bartonellosis, Bacterial Endocarditis Prevention, Cervicitis, Pertussis, Typhoid Fever, Toxoplasmosis, Tonsillitis/Pharyngitis, STD Prophylaxis, Skin or Soft Tissue Infection, Skin and Structure Infection, Pneumonia, Pharyngitis, Pertussis Prophylaxis, Otitis Media, Pelvic Inflammatory Disease, Chancroid, Nongonococcal Urethritis, Mycobacterium avium-intracellulare - Treatment, Mycobacterium avium-intracellulare - Prophylaxis, Lyme Disease - Erythema Chronicum Migrans, Legionella Pneumonia, Granuloma Inguinale, Gonococcal Infection - Uncomplicated, Cystic Fibrosis, COPD - Acute, Bronchitis, Mycoplasma Pneumonia. azithromycin may also be used for purposes not listed in this medication guide. " Azithromycin is an antibiotic used to treat a variety of different infections. It has the distinct advantage of once-daily dosing; however, diarrhea is a common side effect. more Prescribed for Dental Abscess, Upper Respiratory Tract Infection, Skin or Soft Tissue Infection, Bacterial Endocarditis Prevention, Bronchitis, Bowel Preparation, Bullous Pemphigoid, Pemphigoid, Syphilis - Early, Strep Throat, Rheumatic Fever Prophylaxis, Pneumonia, Pharyngitis, Pertussis, Ocular Rosacea, Otitis Media, Campylobacter Gastroenteritis, Nongonococcal Urethritis, Bartonellosis, Lymphogranuloma Venereum, Lyme Disease, Legionella Pneumonia, Chlamydia Infection, Chancroid, Mycoplasma Pneumonia. erythromycin may also be used for purposes not listed in this medication guide. People treated with appropriate antibiotics in the early stages of Lyme disease usually recover rapidly and completely. Antibiotics commonly used for oral treatment include doxycycline, amoxicillin, or cefuroxime axetil. People with certain neurological or cardiac forms of illness may require intravenous treatment with antibiotics such as ceftriaxone or penicillin. Treatment regimens listed in the following table are for localized (early) Lyme disease. See references below (Hu 2016; Sanchez 2016) for treatment of patients with disseminated (late) Lyme disease. These regimens are guidelines only and may need to be adjusted depending on a person’s age, medical history, underlying health conditions, pregnancy status, or allergies. For people intolerant of amoxicillin, doxycycline, and cefuroxime axetil, the macrolides azithromycin, clarithromycin, or erythromycin may be used, although they have a lower efficacy.
Comparison of the effect of azithromycin versus erythromycin on antroduodenal pressure profiles of patients with chronic functional gastrointestinal pain and. Erythromycin and azithromycin are also effective for treatment of. Comparison of Azithromycin versus Erythromycin for Prolongation of Latency in Pregnancies.