Rarely, too much metformin can build up in the body and cause a serious (sometimes fatal) condition called lactic acidosis. Lactic acidosis is more likely if you are an older adult, if you have kidney or liver disease, dehydration, heart failure, heavy alcohol use, if you have surgery, if you have X-ray or scanning procedures that use iodinated contrast, or if you are using certain drugs. For some conditions, your doctor may tell you to stop taking this medication for a short time. Stop taking this medication and get medical help right away if you have any symptoms of lactic acidosis, such as unusual tiredness, dizziness, severe drowsiness, chills, blue/cold skin, muscle pain, fast/difficult breathing, slow/irregular heartbeat, or stomach pain with nausea/vomiting/diarrhea. Show More Metformin is used with a proper diet and exercise program and possibly with other medications to control high blood sugar. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. Metformin works by helping to restore your body's proper response to the insulin you naturally produce. It also decreases the amount of sugar that your liver makes and that your stomach/intestines absorb. Read the Patient Information Leaflet if available from your pharmacist before you start taking metformin and each time you get a refill. J., April 14 /PRNewswire-First Call/ -- Bristol-Myers Squibb Company (NYSE: BMY) today announced that the U. Food and Drug Administration (FDA) has approved Glucophage(R) XR (metformin HCl extended release tablets) 750 mg tablet, a new dosage strength of one of the leading type 2 diabetes therapies. Glucophage XR, which was launched in October 2000, is a once-daily dosage form of Glucophage(R) (metformin hydrochloride tablets). Glucophage XR 750 mg was developed to provide physicians with an additional option to make titration to higher doses more convenient, when needed and appropriate. Glucophage XR is already available in a 500 mg strength and is approved together with diet and exercise for use as initial drug therapy to improve glycemic control for adults 17 years and older with type 2 diabetes when diet and exercise are not enough. In addition to initial therapy, Glucophage XR may be used in combination with a sulfonylurea or insulin to improve glycemic control. More than 10 million prescriptions have been written for Glucophage XR 500 mg. According to the American Diabetes Association, approximately 16 million people in the United States have type 2 diabetes.
Teva's generic medications are available in most pharmacies across the United States, though not all pharmacies carry the same Teva medications. To find out if your medication is available as a Teva generic, contact your local pharmacy. If the pharmacy doesn't regularly stock a certain medication from Teva, ask if it can be ordered for you at no additional cost. Learn More The product catalog provides you with a full listing of Teva's brand and generic product lines. The catalog displays all strengths and sizes along with the description, imprint code, NDC and photo for each product. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Study Design: An Open-Label, Randomized, 2-Period, 2-Treatment, Crossover, Single-Dose Bioequivalence Study An Open-Label, Randomized, 2-Period, 2-Treatment, Crossover, Single-Dose Bioequivalence Study of Metformin Hydrochloride Extended Release 750 mg Tablets (Test Formulation, Torrent Pharmaceuticals Ltd., India) Versus Glucophage XR® 750 mg Tablet (Reference Formulation, Bristol-Myers Squibb Company, USA) in Healthy Volunteers Under Fasting Conditions. Listing a study does not mean it has been evaluated by the U. Choosing to participate in a study is an important personal decision. Objective: To study Bioequivalence of Metformin Hydrochloride Extended Release 750 mg Tablets (Test formulation, Torrent Pharmaceuticals Ltd., India) Versus Glucophage XR® 750 mg Tablet (Reference formulation, Bristol-Myers Squibb company, USA) in Healthy volunteers under Fasting Conditions. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below.
Glucophage and Glucophage XR metformin hydrochloride are oral. is available as tablets while Glucophage XR is available as extended-release tablets. Metformin Hydrochloride Extended-Release Tablets. Biguanides. Strength 750MG. Pack Size Form 100 TABLET BOTTLE. TE Rating AB. Dosage Form.