C10403 is an aggressive and complex treatment regimen for adolescents and young adults (AYA) with ALL. The C10403 regimen is similar to treatment regimens given to pediatric patients (less than 18 y.o.) and is usually considered more aggressive than regimens given to adults (40 years or older). The entire C10403 chemotherapy regimen consists of 5 different treatment courses: induction (this page), consolidation, interim maintenance, delayed intensification, and maintenance. Each of the medications in C10403 are designed to target and kill acute lymphoblastic leukemia cells in the blood, bone marrow, or wherever else they may happen to be. Goals of therapy: C10403 induction is given to eliminate the majority of leukemia cells from the blood and bone marrow. Following induction, the remaining treatment courses are given to eliminate any remaining leukemia cells and maintain remission from the leukemia. The C10403 protocol is commonly given with the goal of cure. Click here for the common C10403 induction starting doses A bone marrow biopsy is typically performed on Day 29, after completion of induction treatment. A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as paroxetine during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, there are also risks when depression is not treated in children and teenagers. Talk to your child's doctor about these risks and whether your child should take an antidepressant, Children younger than 18 years of age should not normally take paroxetine, but in some cases, a doctor may decide that paroxetine is the best medication to treat a child's condition. You should know that your mental health may change in unexpected ways when you take paroxetine or other antidepressants to treat depression or other mental illness even if you are an adult over 24 years of age. You may also experience changes in your mental health if you are a woman taking a low dose of paroxetine to treat hot flashes and you have never had depression or another mental illness. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased.
Tamoxifen withdrawal Tamoxifen withdrawal 2013-02-07 Reactions 797 - Menopausal syndrome 2 case reports Two women, 50 and 43 years of age, developed a withdrawal syndrome characterised by menopausal symptoms a few days after discontinuing tamoxifen. Tamoxifen is a hormonal therapy drug used to treat breast cancer, womb cancer and sometimes other cancers and conditions. It may also be used to prevent breast cancer. It is best to read this information with our general information about hormonal therapies and the type of cancer you have. Tamoxifen is usually given as tablets.