COMPATIBLE: Drug which has been taken by a large number of breastfeeding mothers without any observed increase in adverse effects in the infant. Controlled studies in breastfeeding women fail to demonstrate a risk to the infant and the possibility of harm to the breastfeeding infant is remote; or the product is not orally bioavailable in an infant. PROBABLY COMPATIBLE: Drug which has been studied in a limited number of breastfeeding women without an increase in adverse effects in the infant; And/or, the evidence of a demonstrated risk which is likely to follow use of this medication in a breastfeeding woman is remote. There are no controlled studies in breastfeeding women, however the risk of untoward effects to a breastfed infant is possible, or controlled studies show only minimal non-threatening adverse effects. Drugs should be given only if the potential benefit justifies the potential risk to the infant. (New medications that have absolutely no published data are automatically categorized in this category, regardless of how safe they may be.)POSSIBLY HAZARDOUS: There is positive evidence of risk to a breastfed infant or to breastmilk production, but the benefits of use in breastfeeding mothers may be acceptable despite the risk to the infant (e.g. if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective). In every pregnancy, a woman starts out with a 3-5% chance of having a baby with a birth defect. This sheet talks about whether exposure to sertraline may increase the risk for birth defects over that background risk. This information should not take the place of medical care and advice from your health care provider. Sertraline is a medication that has been used to treat depression, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (a severe form of premenstrual syndrome), and social phobia. Sertraline belongs to the class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). While everyone breaks down medication at a different rate, on average sertraline has a half-life (time it takes to eliminate one half of the drug from the body) of 26 hours. Most of the drug will be out of your system 6 days after stopping sertraline. You should always discuss any changes in your dose or stopping your dose of sertraline with your health care provider. In particular, since some people have withdrawal symptoms when they suddenly stop taking sertraline, your health care provider may suggest that you gradually decrease the dosage that you are taking before you completely stop taking the medication.
ABSTRACT QUESTION Many of my patients who are diagnosed with postpartum depression want to continue breastfeeding. How safe are the newer antidepressant medications during breastfeeding? ANSWER The newer antidepressants transfer into breast milk in low amounts and have not been associated with serious adverse events. Therefore, the antidepressant most effective for the woman should be considered. QUESTION Bon nombre de mes patientes qui ont reçu un diagnostic de dépression postpartum veulent continuer à allaiter. Dans quelle mesure les plus récents médicaments antidépresseurs sont-ils sécuritaires pendant l'allaitement? RPONSE Les plus récents antidépresseurs passent dans le lait maternel en petites quantités et n'ont pas été associés à des événements indésirables sérieux. I'm currently 6 months pregnant with my first child, and while I know I still have some time, I'm the kind of person who likes to plan ahead. Pre-pregnancy I took 25mg of Zoloft once a day for my OCD and anxiety. Due to recent studies of Zoloft being linked to causing fatal damage to the baby's heart, I have been off it since I was three months pregnant. My big question is though, while its unsafe during pregnancy, does that mean its unsafe while breastfeeding as well? Honestly if it's safe I'll be so relieved because I just don't feel comfortable feeding with formula. I have been having aniety since my son was born and have been looking into this and from everthing I've read and after speaking with three dr.'s I have been informed that it is the safest medication of it's kind that can be taken while nursing. With the highest incident of signifigant levels of the drug being in babies uner 8 weeks... I do not know what the right answer is but this is what the studies show. But since pregnancy I've been taking 2grams of DHA a day which I believe has helped a ton.
The combination of breastfeeding and SSRI use has not been studied extensively; however, medication exposure from breastfeeding is less than the exposure that occurs transplacentally. SSRIs are generally considered an option during pregnancy, including citalopram Celexa, fluoxetine Prozac and sertraline Zoloft. Potential complications include an increased risk of heavy bleeding after giving birth postpartum hemorrhage, premature birth and low birth weight.