Sertraline classification

Discussion in 'Canada Pharmacy' started by Dorset, 07-Sep-2019.

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    Sertraline classification


    Efficacy has been demonstrated in depression, dysthymia, OCD, social anxiety, panic disorder, PTSD, premature ejaculation, and premenstrual dysphoric disorder. It's also sometimes used for eating disorders. The core effect of the substance is that it alters mood. This could mean less anxiety, less depression, a more positive outlook, improved cooperation with others, and greater assertiveness. SSRIs may initially worsen symptoms like depression and anxiety in some people. This changes over a period of weeks, with the efficacy building over time. Some benefits in depression may be noticed in the first 1-2 weeks, but the greatest clinical efficacy arrives in the first couple months. Apo-Sertraline (CA), Co Sertraline, Dom-Sertraline, Gen-Sertraline (CA), Lustral (UK), Novo-Sertraline (CA), Nu-Sertraline (CA), PHL-Sertraline (CA), PMS-Sertraline (CA), Ratio-Sertraline (CA), Riva-Sertraline (CA), Sandoz Sertraline (CA), Zoloft • Drug may increase risk of suicidal thinking and behavior in children and adolescents with major depressive disorder (MDD) and other psychiatric disorders. Risk must be balanced with clinical need, as depression itself increases suicide risk. With patient of any age, observe closely for clinical worsening, suicidality, and unusual behavior changes when therapy begins. Advise family and caregivers to observe patient closely and communicate with prescriber as needed. • Drug isn't approved for treating MDD in pediatric patients. Panic disorder; social anxiety disorder; posttraumatic stress disorder Adults: Initially, 25 mg/day P. After 1 week, may increase to 50 mg/day; depending on response, may then increase at weekly intervals to a maximum of 200 mg/day. Use cautiously in: • seizures disorders, severe hepatic or renal impairment, increased risk for suicide • history of mania • concurrent use of serotonergic agents such as tryptophan (use not recommended) • pregnant or breastfeeding patients • children.

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    Dec 23, 2014. Escitalopram, Lexapro. Fluoxetine, Prozac, Sarafem, Symbyax. Fluvoxamine, Luvox, Luvox CR. Paroxetine, Paxil, Paxil CR, Pexeva. Sertraline. Sertraline Zoloft is a prescription medication indicated for the treatment of major depressive disorder and panic disorder in adults. Learn about side effects, drug interactions, dosages, warnings, and more. Anatomical Therapeutic Chemical ATC classification BRbr08303 N NERVOUS SYSTEM N06 PSYCHOANALEPTICS N06A ANTIDEPRESSANTS

    In every pregnancy, a woman starts out with a 3-5% chance of having a baby with a birth defect. This sheet talks about whether exposure to sertraline may increase the risk for birth defects over that background risk. This information should not take the place of medical care and advice from your health care provider. Sertraline is a medication that has been used to treat depression, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (a severe form of premenstrual syndrome), and social phobia. Sertraline belongs to the class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). While everyone breaks down medication at a different rate, on average sertraline has a half-life (time it takes to eliminate one half of the drug from the body) of 26 hours. Most of the drug will be out of your system 6 days after stopping sertraline. You should always discuss any changes in your dose or stopping your dose of sertraline with your health care provider. In particular, since some people have withdrawal symptoms when they suddenly stop taking sertraline, your health care provider may suggest that you gradually decrease the dosage that you are taking before you completely stop taking the medication. Initial: 50 mg q Day PO given continuously throughout menstrual cycle or given during luteal phase only May increase by 50 mg at the onset of each new menstrual cycle; no more than 150 mg q Day when administered continuously or 100 mg q Day when administered during luteal phase only 25 mg PO q Day initially; may increase by 25 mg every 2-3 days; not to exceed 200 mg q Day Alzheimer dementia related depression: Start at 12.5 mg/day and titrate every 1-2 weeks to response; not to exceed 150-200 mg Renal impairment: Dose adjustment not necessary Mild hepatic impairment (Child-Pugh 5-6): Decrease recommended starting dose and therapeutic dose by 50% Moderate-to-severe hepatic impairment (Child-Pugh 7-15): Not recommended; sertraline is extensively metabolized, and the effects in patients with moderate and severe hepatic impairment have not been studied Clinical worsening and suicide ideation may occur despite medication Use caution in patients with seizure disorders May worsen mania symptoms or precipitate mania in patients with bipolar disorder Increases risk of hyponatremia and impairment of cognitive/motor functions in the elderly Increases risk of bleeding in patients taking anticoagulants/antiplatelets concomitantly Risk of mydriasis; may trigger angle closure attack in patients with angle closure glaucoma with anatomically narrow angles without a patent iridectomy Pregnancy: Conflicting evidence regarding use of SSRIs during pregnancy and increased risk of persistent pulmonary hypertension of the newborn (see Pregnancy) In neonates exposed to SNRIs/SSRIs late in third trimester: Risk of complications such as feeding difficulties, irritability, and respiratory problems Avoid abrupt withdrawal Bone fractures reported with antidepressant therapy; consider the possibility if patient presents with bone pain, bruising, or point of tenderness Coadministration with other drugs that enhance the effects of serotonergic neurotransmission (eg, tryptophan, fenfluramine, fentanyl, 5-HT agonists, St. John’s Wort) should be undertaken with caution and avoided whenever possible due to the potential for pharmacodynamic interaction (see Contraindications) May cause false-positive urine immunoassay screening tests for benzodiazepines SSRIs and SNRIs are associated with development of SIADH; hyponatremia reported Several SSRIs (eg, fluoxetine, fluvoxamine, paroxetine, sertraline) are metabolized by CYP2D6 CYP2D6 is involved in the metabolism of approximately 20% of drugs in clinical use and displays large individual-to-individual variability in activity due to genetic polymorphisms More than 80 CYP2D6 variant alleles have been identified; however, 4 of the most prevalent alleles, CYP2D6*3, *4, *5, and *6, account for 93-97% of CYP2D6 poor metabolizers CYP2D6*4, the most common variant (~25% frequency in whites), causes a splicing defect; CYP2D6*3 (2.7% frequency) causes a frameshift mutation; and CYP3D6*5 (2.6%) is an entire deletion of the CYP2D6 gene; individuals homozygous for these alleles have no CYP2D6 activity The impact of CYP2D6 activity is further complicated in some SSRIs (eg, fluoxetine, fluvoxamine, paroxetine, sertraline) because in addition to being substrates for CYP2D6, they are also known to moderately inhibit CYP2D6 activity The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

    Sertraline classification

    Selective Serotonin Reuptake Inhibitors SSRIs Information, Sertraline Zoloft Side Effects, Dosages, Treatment.

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  3. Sep 1, 2017. This sheet talks about whether exposure to sertraline may increase the risk for birth defects over that background risk. This information should.

    • Sertraline Zoloft® MotherToBaby.
    • KEGG DRUG Sertraline.
    • Sertraline By mouth - National Library of. - PubMed Health.

    Sertraline hydrochloride. Zoloft. Pharmacologic classification selective serotonin reuptake inhibitor. Therapeutic classification antidepressant. Pregnancy risk. Feb 9, 2018. Sertraline is an inhibitor of the SERT transporter, this is linked to its mechanism of. Sertraline is classified under pregnancy risk category C. Advice and warnings for the use of Sertraline Zoloft during pregnancy. FDA Pregnancy Category C - Risk cannot be ruled out.

     
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