The cramping, cold sweats, and explosive diarrhea was unimaginable. Its my classic reaction to all new psych drugs and new antiseizure drugs, including neurontin. It is a pain in the you kno what, but I have to do what I have to do! I thought I was going to pass out the pain was so bad. Plaquenil itself I've never had an issue with, but there was a med I was given for a UTI that I didn't know was NOT supposed to be with food that gave me that kind of reaction. I wasn't too bad with Plaquenil until I doubled the dose a few weeks ago to 400mg. What class of drugs is plaquenil Chloroquine resistance vivax Stop hair loss plaquenil Chloroquine resistant malaria drug of choice Question. I started taking Plaquenil 4 weeks ago for non specific autoimmune disease as indicated by ANA. Symptoms were low grade temperature off and on for a year, joint pain and fatigue. I have already felt some relief. Some nauseau at first but less problem with fever and joint pain. But, now I have started having stomach cramps and diarrhea. Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage is also based on weight. Find information about common, infrequent and rare side effects of Hydroxychloroquine Oral. Hopefully, it's like Lynwood said - a one time anomaly. I didn't think it was going to be like this though! I really have to shift the burden off my liver whenever I can. Love, Marji I am going on week three with the plaq and I have worked out a little routine. I did give myself a much needed cleanse though..... You might want to check the website it's a great drug interaction website that also checks some foods & seasonings Sorry you had that nasty episode, I bet it's a one-time combo of some kind that did you in. Then I had explosive diarrhea I've settled down a bit but about once a week I have a really bad blow out. But I'm starting to feel a lot better with my other symptoms, so a little digestive discomfort is worth it I suppose. Can hydroxychloroquine cause diarrhea Hydroxychloroquine Oral Uses, Side Effects, Interactions., Plaquenil Oral Uses, Side Effects, Interactions. Chloroquine help with payment for prescriptionsPlaquenil and rapid heartbeatTreatment of rheumatoid arthritis with methotrexate and hydroxychloroquineChloroquine drug interactionsMg for an average person on plaquenil Hydroxychloroquine can cause an upset tum, it's a common side effect so it could be the longer you're taking it there's a build up effect. Trouble is you've other things coming up so it could be nervous tum, or even the two both making your tum particularly sensitive. Stomach upset or hydroxychloroquine? Good morning. - NRAS. Common and Rare Side Effects for Hydroxychloroquine Oral. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. I can only tolerate one 200mg dose of plaquenil a day. I allergic to sulfa, and the full does causes my skin to break out in an itchy burning rash from scalp to toes, and everywhere in between. So, I do not have stomach issues, probably because of that. However, the methotrexate does cause some intestinal distress the following day. If your child is taking any drugs that can cause a certain type of heartbeat that is not normal prolonged QT interval. There are many drugs that can do this. Ask the doctor or pharmacist if you are not sure. This is not a list of all drugs or health problems that interact with this drug.