Alternatively, we suggest using this opportunity to take a little break from work and read some of the interesting articles below. Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Chloroquine treatment typing discrepancy Chloroquine resistant areas map Methotrexate Moderate Hydroxychloroquine may reduce the renal clearance of methotrexate; the exact mechanism of this interaction is unknown. The mean AUC of methotrexate was increased 52% and the mean Cmax was reduced 17% when a single dose of methotrexate was given with a dose of hydroxychloroquine 200 mg oral. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Sulphasalazine 1. Mechanism of action and Pharmacology 2. Efficacy in Juvenile Idiopathic Arthritis 3and administration 4. Safety 5interaction 6. Monitoring and supervision 7. Formulary 8. Summary recommendations 4. Cyclosporin 1. Mechanism of action and Pharmacology 2. Efficacy in Juvenile Idiopathic Arthritis and Macrophage Activation. It may prevent joint damage and reduce the risk of long-term disability. It can decrease the pain and swelling of arthritis. Plaquenil mechanism of action arthritis Discontinued Plaquenil.other options?, Hydroxychloroquine - Wikipedia Does plaquenil lower blood sugarDosing plaquenil calculatorHydroxychloroquine dosing guidelinesWart plaquenil Although the exact hydroxychloroquine mechanism of action is unknown when used to treat rheumatic diseases like rheumatoid arthritis, hydroxychloroquine inhibits communication between immune system cells. Hydroxychloroquine comes in a 200 mg tablet that are taken by mouth. 1, 2, 3, 5 Hydroxychloroquine Plaquenil Success, Reviews and Side Effects. Review of Disease Modifying Anti Rheumatic disease. Hydroxychloroquine for Crohns Disease and Ulcerative Colitis.. Apr 10, 2019 Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Important information Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine HCQ, a molecule derived from quinacrine, was first used as an antimalarial agent in 1955. 71 Shortly thereafter, HCQ was commonly used as an anti‐inflammatory and immunomodulatory agent at a dose of 200–400 mg/day for the treatment of autoimmune diseases, such as rheumatoid arthritis RA and systemic erythaematosus. Hydroxychloroquine HCQ, a drug which has been used for more than 50 years in the treatment of SLE, has long been considered a relatively minor component in the treatment of systemic lupus erythematosus SLE. However, increasing evidence shows that HCQ is an important medication for this disease 1.