B, Brown pigmentation on the legs in another patient who had systemic lupus erythematosus associated with diffuse discoid lupus. The skin biopsy was performed on the brown area distant from discoid lesions. Efectos secundarios de hydroxychloroquine 200 mg Plaquenil and log qt An African American woman, aged 50 years, presents with painless “bruises” on her leg. She first noticed bruises on both legs a year ago and reports that they have since become larger. Woman With Blue-Gray Palate and Nail Beds. Melikoglu MA, Melikoglu M, Gurbuz U, et al. Hydroxychloroquine-induced hyperpigmentation a case report. We herein report a case of hydroxychloroquine‐induced hyperpigmentation. A 58‐year‐old woman had a 1‐year history of asymptomatic bluish‐gray hyperpigmentation on her neck, upper trunk and upper extremities. She was diagnosed with rheumatoid arthritis 4 years prior and treated with hydroxychloroquine 200 mg/day for 4 years. B, Presence of iron in the same areas of the dermis (Perls staining, original magnification ×100). Pub Med Google Scholar Crossref Morrison LK, Nordlund JJ, Heffernan MP. Pub Med Google Scholar Costedoat-Chalumeau N, Galicier L, Aumaître O, et al; Group PLUS. Google Scholar Costedoat-Chalumeau N, Amoura Z, Hulot JS, et al. Pub Med Google Scholar Crossref Costedoat-Chalumeau N, Leroux G, Piette J-C, Amoura Z. A, Interstitial and perivascular brown pigmented granules in the dermis (hematoxylin-eosin-safran staining, original magnification ×100). Woman in grey hydroxychloroquine-induced hyperpigmentation Woman in grey hydroxychloroquine-induced hyperpigmentation., Woman With Blue-Gray Palate and Nail Beds Clinician Reviews Chloroquine maculopathyCan plaquenil cause dry mouthOct hydroxychloroquine retinopathyHow is plaquenil excretedHydroxychloroquine cardiac protective Hydroxychloroquine-Induced Pigmentation in Patients With Systemic Lupus Erythematosus A Case-Control Study JAMA Dermatol, July 3, 2013. Full text $30. Twenty-four patients with systemic lupus erythematosus developed pigmentation after treatment with hydroxycloroquine for a median of 6.1 years. Most patients reported that the pigmented lesions. RA and Unemployment, Lupus and Bruising, and Rheumatic Fever.. Hydroxychloroquine‐induced hyperpigmentation, The Journal.. Talk Hydroxychloroquine-Induced Hyperpigmentation in.. In our case, infrared spectroscopy enabled us to identify meropenem in the dermis. Two cases of cutaneous hyperpigmentation have been reported following use of levofloxacin, and the results of histological examination were similar. This is the first case of cutaneous hyperpigmentation induced by meropenem. Woman With Blue-Gray Palate and Nail Beds Susan Chrostowski, MS, RN, ANP, Barbara Gray, PhD, RN, CPNP, Peggy Mancuso, PhD, RN, CNM, CNE GRANDROUNDS Susan Chrostowski practices at Rheumatology Associates in Dallas. Bar-bara Gray is an Associate Professor and Peggy Mancuso is a Professor at Texas Woman’s University in Dallas. FIGURE 1 Hydroxychloroquine-related skin discoloration. Woman in grey Hydroxychloroquine-induced hyperpigmentation. clinical features and risk factors of hydroxychloroquine-induced pigmentation.