Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. When should you take plaquenil How much plaquenil medication cost Hydroxychloroquine and blood sugar Spectral Domain Optical Coherence Tomography SD-OCT shows that there is early thinning of outer retinal layers, typically with loss of the parafoveal photoreceptor inner segment/outer segment IS/OS junction and central foveal sparing. There is preservation of the RPE and external limiting membrane. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. OCT. The classic retinal toxicity has been described as “bull's-eye maculopathy,” with the appearance of a ring of parafoveal RPE depigmentation. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Hydroxychloroquine retinopathy oct Toxic Retinopathy With Hydroxychloroquine Therapy - JAMA, Hydroxychloroquine-Induced Retinal Toxicity - American. Does plaquenil cause itchy skinHydroxychloroquine sulphate bp 200mgHydroxychloroquine metabolism Chloroquine and hydroxychloroquine can cause toxic retinopathy due to their binding of melanin in the retinal pigmented epithelium RPE as well as direct toxicity to retinal ganglion cells. Early findings include mottling of the RPE and blunted foveal reflex. As the retinopathy progresses, a bull's-eye maculopathy develops, as seen in these photos. Bull's-eye maculopathy due to hydroxychloroquine toxicity. How to Succeed in Plaquenil Screenings - Review of Optometry. Imaging in Hydroxychloroquine Toxicity April. - Retina Today. Top Fundus autofluorescence FAF and Bottom optical coherence tomography OCT images of an eye with early hydroxychloroquine retinopathy in a 35-year-old Korean patient with systemic lupus erythematosus. Wide-field FAF shows focally increased autofluorescence on the pericentral, inferotemporal area. Marmor MF, Kellner U, Lai TYY, Melles RB, Mieler WF, for the American Academy of Ophthalmology. Recommendations on screening for chloroquine and hydroxychloroquine retinopathy 2016 revision. Ophthalmology 2016;186-1394. Melles RB, Marmor MF. The risk of toxic retinopathy in patients on long-term hydroxychloroquine therapy. Ophthalmology Chloroquine retinopathy, is a form of toxic retinopathy damage of the retina caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs.