Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil 200 in pregnancy Skin changes with plaquenil Focus on Eyes Long-term Plaquenil intake can affect your vision. Taking high doses or long-term treatment of Plaquenil, an anti-malaria drug used to treat lupus, can lead to vision problems. Be sure to notify your other physicians when taking this drug. This drug does not have a strong effect on the immune system, so vaccines recommended by other physicians are generally acceptable. Notify your eye doctor when you are on this medication so regular visual screening tests can be performed. The most important affect of Plaquenil on your eye is to damage the retina at the back of your eye. Fortunately, this is very uncommon and generally only occurs in patients on high doses or patients with bad kidney function. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil does it affect the eyesight Plaquenil Oral Uses, Side Effects, Interactions, Pictures., Hydroxychloroquine Plaquenil Chloroquine autophagy in vivo Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria. Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. Long-Term Side Effects of Plaquenil for Rheumatoid.. Plaquenil & Your Eyes. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. Uncontrolled eye movements unsteadiness, trembling, or other problems with muscle control or coordination vomiting Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. Plaquenil related eye complications are not common. Plaquenil can produce pigment changes in the macula of the retina. The retina is the part of the back of the eye that you see with. The macula is the central part of the retina responsible for central fine vision. With Plaquenil related toxicity, the pigment in the macula can change and alter vision by producing blurring and distortion of objects. PLAQUENIL hydroxychloroquine and the Eye. Download PDFVarious medications can affect the eyes and their drugs can be taken without damaging or changing the eyes in any way. However, a few systemic medications can cause damage to the eyes with subsequent vision changes.