Although survival rates have improved, over one half of patients with systemic lupus erythematosus have permanent damage in one or more organ systems. Arthritis and cutaneous manifestations are most common, but renal, hematologic and neurologic manifestations contribute largely to morbidity and mortality. Can hydroxychloroquine be taken with cholesterol-lowering medications Hydroxychloroquine dose by weight In 1941, discoid lupus patients were treated successfully with Atabrine, a compound developed in Germany in the 1920s. In the mid-1940s, both hydroxychloroquine HCQ and chloroquine CQ had been synthesized. In 1955 HCQ was shown to be effective for both systemic lupus and rheumatoid arthritis. Discoid lupus erythematosus is the most common type of chronic cutaneous lupus CCLE, an autoimmune skin condition on the lupus erythematosus spectrum of illnesses. It presents with red, inflamed, coin-shaped patches of skin with a scaling and crusty appearance, most often on the scalp, cheeks, and ears. It is well known that isolated lesions of chronic discoid lupus erythematosus may be treated by various local applications, e.g. various acids, solid carbon dioxide, and the intralesional injection of gold compounds. 2,3 Recently, we became interested in the report of Ottolenghi-Lodigiani, 4 on the combined intralesional and oral. Systemic lupus erythematosus has fascinated physicians for almost a century and remains the prototypic autoimmune disease. Treatment approaches emphasize using a combination of drugs to minimize chronic exposure to corticosteroids. Chloroquine for discoid lupus Discoid Lupus Erythematosus Medication Antimalarial agents., Discoid lupus erythematosus - Wikipedia Generic name of chloroquinePlaquenil 200mg price in indiaPlaquenil and prednisone interactionHow long has plaquenil been on the marketDrug cost for plaquenil Hydroxychloroquine is used to treat discoid lupus erythematosus DLE or systemic lupus erythematosus SLE or lupus. It is also used to treat acute and chronic rheumatoid arthritis. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms Tablet; Before Using Hydroxychloroquine Oral Route Description and Brand.. Chloroquine for Chronic Discoid Lupus Erythematosus Intralesional.. Aralen Chloroquine MyLupusTeam. Chloroquine phosphate is used occasionally to decrease the symptoms of rheumatoid arthritis and to treat systemic and discoid lupus erythematosus, scleroderma, pemphigus, lichen planus, polymyositis, sarcoidosis, and porphyria cutanea tarda. Talk to your doctor about the possible risks of using this drug for your condition. In active rheumatoid arthritis and systemic and discoid lupus erythematosus, to avoid excessive dosage in obese patients, the daily maximum dose should be calculated on the basis of ideal body weight. Results This article reports successful treatment of refractory hypertrophic discoid lupus with combination therapy that included chloroquine 250 mg/d, quinacrine 100 mg/d, and actitretin 25 mg/d.