While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. "Hydrochloroquine (Plaquenil) has been a blessing for me. Chloroquine mice scratching Plaquenil tb Chloroquine fansidar and mefloquine Aralen malaria medication Does anyone take methotrexate and hydroxychloroquine and has anyone had problems with hydroxychloroquine. No joke I had to come off purely because I thought I was going to take off in work. Not good for credibility let me tell you xxxx Fi. Reply 0 Report. Hidden. in reply to Hidden. Plaquenil takes quite a long time to get to its peak effectiveness depending on what you read, anywhere from 3 months to a year. Unless you are having significant side effects, try to give it at least 6 months before you decide it doesn't work for you. No methotrexate doesn't always mean your hair will fall out or thin but some of the side effects are scary, but before you an progress onto other meds methotrexate is mandatory. for me methotreaxte and plaquenil does't work and i' intonate of sulfa so i am started embrel which states you have to have tried 2 of 3 meds and methotrexate is 1 of them. I do occasionally experience dry eyes and a little scalp itch but asserting that it's caused by Hydrochloroquine would be anecdotal at best. It took about 5 weeks to take effect but my RA is basically a non factor now. When plaquenil doesn t work Ask the Expert Plaquenil and Sjögren’s, PLAQUENIL" Rheumatoid Arthritis Community - Support Group Can i buy hydroxychloroquine from canadaPlaquenil lupus anticoagulantRetinal deposits plaquenil infared imagingBenefits drawbacks hydroxychloroquine Hydroxychloroquine oral tablet doesn’t cause drowsiness, but it can cause other side effects. More common side effects. The more common side effects that can occur with hydroxychloroquine include Hydroxychloroquine Side Effects, Dosage, Uses, and More. What next if plaquenil doesn't work?. If Plaquenil doesn't work. Lupus Forums at The Lupus Site. Here are 10 things to keep in mind when using Plaquenil Take it on a regular schedule, meaning at the same time each day. Take Plaquenil EXACTLY as prescribed by your physician. Do not stop taking the medication without first speaking to your doctor. Taking Hydroxychloroquine with food and/or milk can help prevent stomach upset. Plaquenil is supposed to help with hair loss, not contribute to it. I would also suggest giving it some more time especially since the side effects of plaquenil are supposed to lessen after a few months of use. Hydroxychloroquine Plaquenil, chloroquine Aralen, and quinacrine Atabrine are medications that were originally used to prevent or treat malaria. However, during World War II it was also found that these medications were effective in treating the symptoms of lupus.