Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Neostigmine chloroquine phosphate Hydroxychloroquine hypercalcemia Methotrexate Moderate Hydroxychloroquine may reduce the renal clearance of methotrexate; the exact mechanism of this interaction is unknown. The mean AUC of methotrexate was increased 52% and the mean Cmax was reduced 17% when a single dose of methotrexate was given with a dose of hydroxychloroquine 200 mg oral. Methotrexate Anti-Rheumatic Oral, Rheumatrex Oral, Trexall Oral. All generic drug interactions for methotrexate sodium oral lists will include brand and generic names 10 contraindicated drug interactions. 79 serious drug interactions. 179 significant drug interactions. Plaquenil takes 2-3 months to work up to a therapeutic dose - it's not for addressing flares and then reducing dosage afterward - it needs to be maintained at a constant dosage to do it's job of slowing disease other medications I mentioned, particularly prednisone, are often adjusted as flares ebb and flow. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Prilosec methotrexate prednisone plaquenil interactions Why take plaquenil for lupus - Answers, Methotrexate sodium oral and omeprazole oral Drug. Chloroquine diphosphate intercalator dna Interactions between your drugs. Using methotrexate together with predniSONE can increase the blood levels or add to the side effects of methotrexate Talk with your doctor before using these medications together. . Newbie here. Humira with Plaquenil. Plaquenil Oral Interactions with Other Medication. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is. Learn about drug interactions between methotrexate sodium oral and omeprazole oral and use the RxList drug interaction checker to check drug combinations. Hello hope everyone is well just a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works.