Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine cream side effects Is chloroquine safe in early pregnancy Can i take tylenol with plaquenil Can plaquenil help osteoarthritis According to the American College of Rheumatology, hydroxychloroquine Plaquenil, is a “disease-modifying anti-rheumatic drug DMARD,” meaning that it helps reduce the pain and swelling that come with arthritis. It can also reduce the incidence of joint damage, thus lessening the risk of developing a long-term disability from. Hi Phoebe, I have been on plaquenil for many years and have not experienced a sudden onset of fatigue after taking it. While those of us with lupus never truly find anything to relieve fatigue, plaquenil is suppose to help with fatigue rather than create more from what I understand. Plaquenil is a medication that most people with Lupus or a connective tissue disease will be on. The downside is that it takes 3-6 months to start working. I've been on it for 5 months now and I am definitely seeing an improvement. I have more energy, my joints are better and I've had far fewer nose/mouth ulcers. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. More energy on plaquenil Ask the Expert Plaquenil and Sjögren’s, Does Plaquenil make you tired? DailyStrength Chloroquine is chloroformPlaquenil medicine side effectsChloroquine and neuropathyPlaquenil and surgery risk Jun 22, 2012 As you adjust to the plaquenil you will feel some energy surges. At least I did. The fatigue you're feeling is from you feeling better and trying to do more. I know it's hard, but you need to rest when the fatigue hits or you need to save up your energy to avoid the fatigue. You'll feel the full effect of the plaquenil about 3 months in. Side Effects of Plaquenil -. Starting Plaquenil DailyStrength. Treatment/Plaquenil -. Sep 13, 2019 Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Jan 11, 2012 I hadn't really considered it, but I had to take a break from the plaquenil because of stomach issues. Thankyou all for the suggestions to restart slowly, by the way. I'm tolerating it much better. I had only been taking it for a couple weeks and I already seemed to have more energy. About a week after I stopped taking it I had a wicked flare. Dosage for Plaquenil. The adult dose of Plaquenil to suppress malaria is 400 mg on the same day each week. The pediatric weekly suppressive dosage is 5 mg/kg of body weight. The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days.