Most importantly, you help support continued development of this site. The majority of cases of retinotoxicity have occurred in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine (Plaquenil). This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day (200 bid). Plaquenil effects on diarrhea Plaquenil yeast infection Plaquenil and allergy testing She’s worried about undertreatment and believes that the previous AAO guideline, up to 6.5 mg/kg per day ideal weight, was fine, “with some understanding that there are high-risk groups, such as the elderly and people with renal impairment, where the dose should be reduced.” The current recommended maximal dose for hydroxychloroquine is 6.5 mg/kg/day, with the weight in kilograms used for this calculation being the ideal bodyweight rather than actual bodyweight. We consider this supportive of dosing based on actual body weight 6.5 mg per kg with a cap at 400 mg per day. From a practical perspective, this means the daily dose should be reduced, from 400 mg per day, for those weighing less than 61 kg 134lbs. Hydroxychloroquine Blood Levels and Adherence It now solely uses real body weight (rather than ideal body weight) based on new recommendations from a 2014 study (1). Disclaimer: This tool is designed to help eye care professionals better understand the risk the of retinotoxicity from hydroxychloroquine. Please note: This calculator was modified in 9/2015. Hydroxychloroquine weight based dosing 5 mg kg ideal bo NEW DOSE RECOMMENDATIONS FOR PLAQUENIL. - Lupus., Dosage of hydroxychloroquine should be based on ideal body. Plaquenil and muscle relaxers interactions SAN FRANCISCO – Hydroxychloroquine Plaquenil dosing based on actual body weight – instead of ideal weight – is appropriate for patients with systemic lupus erythematosus SLE, according to a review of 686 lupus patients at Johns Hopkins University in Baltimore. Most were dosed by actual weight, 6.5 mg/kg up to a maximum of 400 mg/day. ACR Actual-weight hydroxychloroquine dosing works in SLE, up to a.. The Role of Hydroxychloroquine Blood Levels in SLE RheumNow.. ARVO Hydroxychloroquine daily dosing recs often exceeded. Excess Hydroxychloroquine Dosing All Too Common. 54.3 percent of patients who started HCQ before the 2011 recommendations were exceeding the 2011 dosing threshold of 6.5 mg/kg/day per ideal body weight, compared with 49.4 percent who started HCQ therapy after the 2011 guidance. the authors note that the likelihood of a “safe” dose of. Hydroxychloroquine HCQ retinopathy may be more common than previously recognized; recent ophthalmology guidelines have revised recommendations from ideal body weight IBW-based dosing to actual body weight ABW-based dosing. However, contemporary HCQ prescribing trends in the UK remain unknown. We examined a UK general population database to investigate HCQ dosing between 20. We. Based on these risks, the American Academy of Ophthalmology AAO recommends not exceeding a daily hydroxychloroquine dosage of 5 mg/kg using actual body weight in most patients. Previous recommendations to use ideal body weight are no longer advised; very thin patients in particular were at increased risk for retinal toxicity using this practice.