Metformin vs gliclazide

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  1. Jobinet Moderator

    Metformin vs gliclazide


    New research suggests that gliclazide added to metformin in the treatment of type 2 diabetes (T2D) is associated with the lowest risk of hypoglycemia when compared with the newer generation sulphonylureas (SUs) (). Adding SUs, such as gliclazide, glipizide, glimepiride, and glibenclamide, to metformin remains a common strategy for treating T2D, but individual SUs differ and may confer different risks of abnormally low blood sugar. Corresponding author Stig Ejdrup Andersen, MD, Ph D, Roskilde University Hospital (Denmark), and his coauthor conducted a systematic review of randomized controlled trials lasting between 12 to 52 weeks and evaluated SUs added to inadequate metformin monotherapy (≥ 1000 mg/day) in those with T2D. They found that in 16,260 patients from 13 trials of SUs and 14 trials of oral non-SU anti-hyperglycemic agents, the risk of hypoglycemia was lowest with gliclazide compared to glipizide (OR 0.22, Cr I [credible interval] 0.05 to 0.96), glimepiride (OR 0.40, Cr I 0.13 to 1.27), and glibenclamide (OR 0.21, Cr I 0.03 to 1.48). “Risk of hypoglycemia with the SU agents makes the newer and more expensive antidiabetics preferable when metformin monotherapy fails. However, our data indicate that the risk of hypoglycemia differs between the SU agents,” said Dr Andersen. “Thus, prescribing an SU with low risk of hypoglycemia might still be a rational and affordable alternative to many patients with type 2 diabetes.” One major limitation of the review, authors note, is the varying definitions of hypoglycemia across studies. Not all diabetes drugs are equally effective at preventing death and heart disease over a decade-long period, a new study suggests. Diabetes patients who take some versions of drugs called insulin secretagogues are 20 to 33 percent more likely to die from any cause over a 10-year period than patients who take the diabetes drug metformin, the study said. Insulin secretagogues have been around since the 1950s and work by stimulating cells to produce insulin, while metformin works by reducing excess sugar seen in Type 2 diabetes. But the findings do not suggest that insulin secretagogues are harmful to people only that some seem to be less effective than metformin , said study researcher Dr. Tina Ken Schramm, a senior resident at the Heart Center at Rigshospitalet Copenhagen University Hospital in Denmark. Metformin is doctors' first choice for treating Type 2 diabetes, Schramm said. But the drug "is contraindicated in patients with renal failure, severe heart failure and when patients are intolerant to metformin," she told My Health News Daily, which explains why not all diabetes patients can take metformin.

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    The maximum dose of gliclazide, metformin, and acarbose was 120 mg/d, 1,700 mg/d, and 300 mg/d, respectively. The therapeutic target was defined as HbA 1c 7.0%. The study protocol was approved by the Ethics Review Board of Tongji University. Metformin is popular because it doesn’t increase the amount of insulin in the body so it doesn’t have the risk of bringing blood sugars down too low hypoglycemia like Gliclazide would. Gliclazide works by stimulating the beta cells in the pancreas and raising the levels of insulin produced in the body. One hundred and eighty T2DM patients were randomly allocated for treatment with placebo control, metformin 500 mg twice daily, glimepiride 3mg once daily, gliclazide 80 mg once daily, metformin plus glimepiride or metformin plus gliclazide for 3 months.

    New research suggests that several commonly prescribed drugs for Type 2 diabetes may not be as effective at preventing death and cardiovascular diseases, such as heart attacks and stroke, as the oral anti-diabetic drug, metformin. New research suggests that several commonly prescribed drugs for type 2 diabetes may not be as effective at preventing death and cardiovascular diseases, such as heart attacks and stroke, as the oral anti-diabetic drug, metformin. Insulin secretagogues (ISs),* such as glimepiride, glibenclamide (known as glyburide in the USA and Canada), gliclazide and tolbutamide, have been used to treat type 2 diabetes since the 1950-1970s, Nevertheless, the long-term risk associated with these drugs has largely been unknown. Metformin is the first drug of choice in type 2 diabetes, but, until now, there have not been studies investigating the long-term risk of individual ISs compared with metformin. A study published online April 6 in the followed a large, unselected group of everyone living in Denmark, aged over 20, who had been treated with either an IS or metformin (monotherapy) between 19 -- a total of 107,806 people. It found that, compared to metformin treatment, monotherapy with most ISs, including glimepiride, glibenclamide, glipizide and tolbutamide, was associated with a greater risk of death from any cause, and a greater risk of heart attacks, stroke or death from cardiovascular diseases. This was the case both for patients who had already suffered a heart attack and for patients who had not. Gliclazide belongs to the class of medications known as oral hypoglycemics. It is used for the control of blood glucose in people with type 2 diabetes. It is used when diet, exercise, and weight reduction have not been found to control blood glucose well enough without medication. Gliclazide increases the amount of insulin released by the pancreas and helps the body use insulin more efficiently. This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

    Metformin vs gliclazide

    Diabetes Drugs Some Work Better Than Others - Live Science, Gliclazide and metformin ? Diabetes discussions Body.

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  7. Metformin, marketed under the trade name Glucophage among others, is the first-line medication for the treatment of type 2 diabetes.

    • Metformin - Wikipedia.
    • Effects of metformin plus gliclazide versus metformin plus..
    • Combination Therapy with Metformin plus Gliclazide in Patients with..

    Condition or disease, Intervention/treatment, Phase. Diabetes Mellitus, Type 2, Drug vildagliptin Drug Gliclazide Drug Metformin, Phase 3. Moreover, in our present study, statin use was significantly lower in the metformin group as compared with the glipizide group 59.5 vs. 73.7%; P = 0.013 at the end of the study. However, no significant difference was found in the lipid levels between the two groups after treatment, even with a tendency of slightly higher triglyceride levels. Gliclazide has a completely different way of working than Metformin. Gliclazide stimulates the pancreas to produce more insulin. Metformin helps the liver reduce it's glucose output a bit and reduces your appetite a bit.

     
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