Tamoxifen use in men

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    Tamoxifen use in men


    Please note: This article was published more than one year ago. The facts and conclusions presented may have since changed and may no longer be accurate. Questions about personal health should always be referred to a physician or other health care professional. 16, 2011 (Health Day News) -- One in five male breast cancer patients stops taking the drug tamoxifen early due to side effects caused by the medicine and may be at increased risk for cancer recurrence, new research suggests. Tamoxifen is the standard of care for the hormone treatment of male breast cancer patients, according to the authors of a new report published in the Nov. In the study, researchers at the University of Texas M. Anderson Cancer Center in Houston examined the records of 64 male breast cancer patients who received tamoxifen for an average of four years and found that 34 of them (53 percent) experienced one or more tamoxifen-related side effects, such as weight gain and loss of sex drive. Thirteen (20.3 percent) of the patients stopped taking tamoxifen due to the side effects. Nine of the patients died after they discontinued tamoxifen early, the study authors noted in a journal news release."This is the largest study to specifically assess tamoxifen-related side effects in men because in our institution we treated a relatively large number of male breast cancer patients," study author Dr. As there are so few male breast cancer cases, clinical practice and optimal treatment strategies have been extrapolated from female breast cancer patients with very little published evidence to guide clinical decisions. Naveen Pemmaraju said in the news release."We found that, after adjusting for patient age and stage of the disease, the prognosis for men with breast cancer is similar to that of women. In our institution, we noted that several of our male patients were having difficulty with taking tamoxifen therapy, and these side effects appeared to be a little bit different to those reported with women receiving the same drug," Pemmaraju continued."The results of this study should not change the recommendation for prescribing tamoxifen for male breast cancer patients. Tamoxifen has been shown to improve survival rates for breast cancer patients, so early discontinuations may have the potential to increase the risk of the cancer recurring in this group of male breast cancer patients," he added."Male breast cancer is a very rare and unique cancer affecting approximately 2,000 men in the U. However, clinicians need to be aware of the possible side effects that men may experience when receiving tamoxifen so that the patients can be counseled appropriately," he added. National Cancer Institute has more about male breast cancer. Tel: 1-713-792-2817; Fax: 1-713-794-4385; E-mail: [email protected] reviewed male breast cancer patients evaluated at our institution (1999–2009). Giordano, Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, 1115 Hermann Pressler Drive, Houston, TX 77030, USA. Of 126 patients, 64 met the following inclusion criteria: stage I–III, treated with tamoxifen, at least one follow-up visit after starting tamoxifen. A descriptive analysis of toxic effects was carried out on these 64 patients. Thirty-four (53%) patients experienced one or more toxicity while taking tamoxifen. Most common toxic effects are weight gain (14 patients, 22%) and sexual dysfunction (14 patients, 22%). Thirteen (20.3%) patients discontinued tamoxifen due to toxicity: one ocular, one leg cramps, two neurocognitive deficits, two bone pain, three sexual dysfunction, and four thromboembolic events. To our knowledge, this is the largest study examining tamoxifen-related toxic effects among male breast cancer patients.

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    Of these 64 patients, 20.3% 13 of the men discontinued taking their prescribed tamoxifen therapy early because of the side effects. For men, tamoxifen can cause * headache * nausea and vomiting * skin rash * sexual side effects like erectile dysfunction or a lower sex drive Tamoxifen, sold under the brand name Nolvadex among others, is a medication that is used to prevent breast cancer in women and treat breast cancer in women and men. It is also being studied for other types of cancer. It has been used for Albright syndrome. Tamoxifen is typically taken daily by mouth for five years for breast cancer.

    Dear Onco Link "Ask The Experts,"Having had a mastectomy in July 2005, I was prescribed Tamoxifen. Adjuvant systemic therapy for male breast carcinoma. I am having difficulty in finding any information on the side effects [of this drug] in men. I appreciate that we are a small number [of all breast cancer patients], but information for breast cancer in men is limited. Can you please advise on any side effects of Tamoxifen in men? Carolyn Vachani RN, MSN, AOCN, Onco Link's Nurse Educator, responds: Tamoxifen is generally accepted as the standard of care for adjuvant systemic hormonal therapy (that is, therapy given in addition to local treatment, such as surgery and/or radiation) in breast cancer. Tamoxifen improves survival rates in women with estrogen receptor-positive cancer, and since male breast cancer is hormone receptor-positive in about 90% of cases, hormonal therapy in men makes sense. There are few, if any, randomized clinical trials that have assessed tamoxifen use in men. Tamoxifen won't work on hormone-receptor-negative breast cancer. Tamoxifen is available in two forms: a pill taken once a day (brand name: Nolvadex) or a liquid form (brand name: Soltamox). If you dislike pills or you're having trouble swallowing tamoxifen pills, Soltamox can help make it easier to stay on your treatment plan. Most doctors recommend taking tamoxifen at the same time each day. — while you are taking tamoxifen and for 2 months afterward. You should not take tamoxifen if you are breastfeeding, pregnant, trying to get pregnant, or if there is any chance that you could be pregnant. You should use an effective non-hormonal type of birth control — such as condoms, a diaphragm along with spermicide, or a non-hormonal I. Ask your doctor which type of non-hormonal birth control would be best for you. Since its approval in 1998, tamoxifen has been used to treat millions of women and men diagnosed with hormone-receptor-positive breast cancer. While an aromatase inhibitor is the first hormonal therapy medicine choice for postmenopausal women, tamoxifen is the first choice for premenopausal women and is still a good choice for postmenopausal women who can't take an aromatase inhibitor.

    Tamoxifen use in men

    Tamoxifen Nolvadex - Side Effects, Dosage, Interactions - Drugs, Does tamoxifen produce side effects in men? - WebMD

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  4. One of the largest retrospective studies specifically examining tamoxifen-related side-effects among male breast cancer patients treated with.

    • Retrospective review of male breast cancer patients analysis of..
    • Tamoxifen - Wikipedia.
    • Tamoxifen to treat male pubertal gynaecomastia - ScienceDirect.

    Tamoxifen is the best studied. but they have not been well-studied in men. Still, some doctors use them to. Targeted Therapy for Breast Cancer in Men; The study also found a 22% rise in the numbers using tamoxifen, and the chief researcher, Professor Bruce Davis, discovered that male. Tamoxifen is a drug called an estrogen receptor antagonist, which works by blocking. As a result, tamoxifen is commonly used to prevent breast cancer from appearing or. Men who are able to do ten push-ups are less likely to have a stroke.

     
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