D., West Virginia University Hospitals, Morgantown, West Virginia MELANIE A. Part II, “Vaginal Infections, Pelvic Inflammatory Disease and Genital Warts,” will appear in the next issue of In 1998, the Centers for Disease Control and Prevention released guidelines for the treatment of sexually transmitted diseases. SC., West Virginia University, Morgantown, West Virginia Am Fam Physician. This is Part I of a two-part article on drug treatment of common sexually transmitted diseases. Several treatment advances have been made since the previous guidelines were published. Part I of this two-part article describes current recommendations for the treatment of genital ulcer diseases, urethritis and cervicitis. Treatment advances include effective single-dose regimens for many sexually transmitted diseases and improved therapies for herpes infections. Two single-dose regimens, 1 g of oral azithromycin and 250 mg of intramuscular ceftriaxone, are effective for the treatment of chancroid. 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