Combining prescription medications with alcohol can have serious side effects. This is especially the case if the drug used and alcohol have similar effects. One example of a medication abused along with alcohol is clonidine. Clonidine isn’t a scheduled substance because it’s primary purpose is to treat hypertension, and it’s not abused as frequently as opioids and benzodiazepine tranquilizers. Besides hypertension, clonidine – also known by the brand name Catapres – is used to treat anxiety disorders, pain disorders, panic attacks, and attention deficit hyperactivity disorder. It’s available in 0.1 mg, 0.2 mg, and 0.3 mg dosages. The drug classifies as a centrally acting alpha-agonist. like xanax Usual dose range is 0.2 to 0.6 mg daily in divided doses. If transdermal patch is used, apply to area of hairless intact skin once q 7 days. Half-life of clonidine ranges from 6 to 20 hours in patients with normal renal function. b.i.d.; then increased by 0.1 per day at weekly intervals until desired response is achieved. Excretion: About 65% of a given dose is excreted in urine; 20% is excreted in feces. Initially, clonidine may stimulate peripheral alpha-adrenergic receptors, producing transient vasoconstriction. Antihypertensive action: Clonidine decreases peripheral vascular resistance by stimulating central alpha-adrenergic receptors, thus decreasing cerebral sympathetic outflow; drug also may inhibit renin release. Or, apply transdermal patch (0.2 mg/24 hours) and replace weekly for the first 2 or 3 weeks after smoking cessation. After oral administration, the antihypertensive effect lasts up to 8 hours; after transdermal application, the antihypertensive effect persists for up to 7 days. Contraindicated in patients hypersensitive to drug. Transdermal form is contraindicated in patients hypersensitive to any component of the adhesive layer. Zithromax dosage for gonorrhea Doxycycline rosacea treatment Viagra challenge Справочник лекарственных препаратов. Полное описание клонидин, рецепт, фармакология и инструкция по применению. will cipro treat mrsa Transdermal TTS-1 releases 0.1 mg/24 hours; TTS-2 releases 0.2 mg/24 hours; TTS-3 releases 0.3 mg/24 hours. Indications and dosages. Hypertension. People who abuse clonidine usually use it in combination with another substance because it tends to. It's available in 0.1 mg, 0.2 mg, and 0.3 mg dosages. It crosses the blood-brain barrier and acts in the hypothalamus to induce a decrease in blood pressure. It may also be administered as an epidural infusion as an adjunct treatment in the management of severe cancer pain that is not relieved by opiate analgesics alone. Clonidine may be used for differential diagnosis of pheochromocytoma in hypertensive patients. Other uses for clonidine include prophylaxis of vascular migraine headaches, treatment of severe dysmenorrhea, management of vasomotor symptoms associated with menopause, rapid detoxification in the management of opiate withdrawal, treatment of alcohol withdrawal used in conjunction with benzodiazepines, management of nicotine dependence, topical use to reduce intraocular pressure in the treatment of open-angle and secondary glaucoma and hemorrhagic glaucoma associated with hypertension, and in the treatment of attention-deficit hyperactivity disorder (ADHD). PO administration: 0.1-0.3 mg q4-6hr; increase by 0.1 mg/day to 0.15-0.75 mg/day if required; do not exceed 2.4 mg/day TD administration: 100-200 mcg/day patch q7Days; initiate 0.1-0.3 mg PO q4-6hr for first 2 days to allow for adequate drug levels Not recommended as routine treatment for hypertension (Beers criteria) Potential for orthostatic hypotension and adverse CNS effects May cause bradycardia Immediate release: Lower initial doses than for nongeriatric adult dosing, as well as gradual adjustments, are recommended Extended release: May require lower initial dose than for nongeriatric adult dosing Skin reactions; patch (15-50%) Dry mouth (40%) Somnolence (19-38%) Headache (19-29%) Fatigue (13-24%) Drowsiness (33%) Dizziness (13-16%) Hypotension, epidural (45%) Postural hypotension, epidural (32%) Anxiety (11%) Epidural clonidine is not recommended for obstetric postpartum or perioperative pain management because the risk of hemodynamic instability (eg, hypotension, bradycardia) may be unacceptable in this population Dilute product with strength of 500 mcg/m L prior to use Epidural: Hemodynamically unstable patients (risk of severe hypotension) Do not discontinue suddenly (risk of rebound hypertension) Patch: May need to remove if severe erythema and/or localized vesicle formation develop at application site or generalized rash; consult physician Severe coronary insufficiency May cause xerostomia Recent MI Cerebrovascular disease Chronic renal failure Raynaud's disease Thromboangiitis obliterans History of depression (may exacerbate depression in cancer patients) May impair ability to perform hazardous tasks Remove patch before MRI (may cause burns) Hypotension may occur; usually responsive to IV fluids and, if necessary, appropriate parenterally administered pressor agents Cardiac conduction abnormalities: Sympatholytic action may worsen sinus node dysfunction and atrioventricular (AV) block, especially if coadministered with other sympatholytic drugs Titrate slowly and monitor vital signs frequently in patients at risk for hypotension, heart block, bradycardia, syncope, cardiovascular disease, vascular disease, cerebrovascular disease or chronic renal failure; measure heart rate and blood pressure prior to initiation of therapy, following dose increases, and periodically while on therapy; avoid concomitant use of drugs with additive effects unless clinically indicated; advise patients to avoid becoming dehydrated or overheated Epidural administration may result in mild respiratory depression (usually with higher than recommended dose) Use with caution in cerebrovascular disease Avoid as first line antihypertensive in the elderly due to high risk for adverse side effects Children may be particularly susceptible to hypertensive episodes when experiencing GI illnesses that lead to vomiting Discontinue oral immediate release formulations within 4 hr of surgery; restart as soon as possible following surgery Due to different pharmacokinetic profiles, oral formulations are not interchangeable with extended release on a mg-mg basis due to different pharmacokinetic profiles Central sympatholytic via stimulation of central alpha receptors; results in reduced sympathetic outflow, causing decreased PVR, HR, BP, and renal vascular resistance; produces presynaptic and postjunctional alpha-2 adrenoreceptor analgesia by preventing pain signal transmission to brain Postsynaptic alpha2-agonist stimulation may regulate subcortical activity in the prefrontal cortex, which may regulate the area of the brain responsible for attention, emotions, and behaviors, and thereby reduces hyperactivity, distractibility, and impulsiveness The above information is provided for general informational and educational purposes only. 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