The main function of the spleen (red pulp) is to filter the blood, removing worn out blood cells and recycling the proteins and iron. It is also a reserve factory for manufacture of blood cells. In horses and some dogs such as greyhounds, the organ is a reserve for the oxygen-carrying red cells required for sudden bursts of activity. In the white pulp, the spleen contains large numbers of lymphocytes and macrophages, cells of the immune system. These cells are involved in recognizing 'foreign', potentially harmful materials like infectious microorganisms, helping destroy them and then providing protection (immunity) against future attack. Tumors of the spleen are common in older dogs, but rare in cats. In some cases, the enlargement may be due to blood accumulating as a result of poor circulation or bleeding within the spleen (hematoma). Sometimes excessive work in making blood components (hemopoiesis) or excessive breakdown of blood cells cause enlargement. lasix with sulfa allergy Our aim is to continually strive for the betterment of agility competition and training for all dogs. As an agility organization, what we have to offer is unique! We also aim to provide trials at which all competitors - whether they are weekend ‘just-wanna-have-fun-with-my-dog’ enthusiasts or die-hard professional agility competitors – are catered for. UK Agility International is run by Greg and Laura Derrett, two internationally recognised and renowned competitors and trainiers. As competitors and trainers we understand the need for quality events that encourage excellence in competition but also the environment that encourages good dog training practices where dogs can be rewarded for correct behaviour. 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Determining for certain whether a patient has canine Addison’s disease is difficult because the clinical signs are vague and mimic those of other diseases that can often be temporarily resolved with fluids and other supportive care. Most of these stones are composed of the mineral salts of common elements found in our bodies, calcium, magnesium, ammonia, phosphorus and carbonates. Their composition and consistency are similar to that of limestone. Several things contribute to the formation of urinary tract stones. If the concentration of mineral salts are too high in the urine, they precipitate out, layer upon layer. This can happen in the kidneys or farther down the tract in the bladder. The urine of dogs and cats should be naturally acidic. Most mineral salts are less soluble in alkaline urine so any factors that make the urine more basic or alkaline contribute to stone formation. 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